Psychological medicine

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Aetiology of Psychiatric Disorders

  • Predisposing factors: Determine a person‟s vulnerability to psychological distress.  Causes include:
    • Genetic endowment (eg strong genetic component in psychosis) 
    • Environment in utero ® minor damage to CNS 
    • Personality: combination of genetic, uterine development, childhood experiences (physical, psychological, social), adolescence. Particular personalities are prone to certain disorders. Eg early obsessional traits may ® obsessive-compulsive disorders
  • Precipitating FactorsFactors that occur shortly before the onset of the disorders and are likely to have caused it. Eg: 
    • Physical: hypothyroidism, drugs, drugs of abuse, head injury (either direct disturbance or due to associated stress)
    • Psychological: eg loss of self-esteem owing to relationship or financial catastrophe
    • Social: eg moving house, changing job, family disturbance
  • Perpetuating factors: Factors that prolong the course of the disorder: eg secondary demoralisation
  • Psychiatric aspects of physical illness
    • Most common psychiatric illnesses in physical illness are mood disorders and acute organic mental disorders 
    • Occurs in one of three ways:
      • Psychological distress can precipitate mental illness
      • Physical distress can cause psychological ill-health (as can the medicines for physical disease) 
      • Physical and psychological disorders may exist simultaneously and independently (especially in the elderly) 
    • Pain: a common medical symptom. Can cause (eg head, neck, lower back, abdomen, genitalia) or arise from psychological disturbance (eg facial pain – antidepressant therapy can be effective).
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